Cationic antimicrobial peptides promote microbial mutagenesis and pathoadaptation in chronic infections PLoS Pathog 10 e Helicobacter pylori genomic microevolution during naturally occurring transmission between adults PLoS One 8 e Cystic fibrosis-niche adaptation of Pseudomonas aeruginosa reduces virulence in multiple infection hosts PLoS One 7 e Proteomic profiling of Burkholderia cenocepacia clonal isolates with different virulence potential retrieved from a cystic fibrosis patient during chronic lung infection PLoS One 8 e Quantitative proteomics 2-D DIGE reveals molecular strategies employed by Burkholderia cenocepacia to adapt to the airways of cystic fibrosis patients under antimicrobial therapy Proteomics 11 Helicobacter pylori : friend or foe?
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It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide. Sign In or Create an Account. Sign In. Advanced Search. Search Menu. Article Navigation. Close mobile search navigation Article Navigation. Volume Lipopolysaccharide modification in Gram-negative bacteria during chronic infection.
Maldonado , Rita F. Oxford Academic. Miguel A. Revision received:. Cite Cite Rita F. Select Format Select format. Permissions Icon Permissions. Open in new tab Download slide. Table 1. LPS genes altered in P. LPS metabolism. Lipid A biosynthesis and modification lpxO2 Cramer et al. Open in new tab. Table 2. Homologous gene in. Gene or locus. Infection with transmissible strains of Pseudomonas aeruginosa and clinical outcomes in adults with cystic fibrosis. Google Scholar Crossref. Search ADS.
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Molecular structures that influence the immunomodulatory properties of the lipid A and inner core region oligosaccharides of bacterial lipopolysaccharides. Google Scholar PubMed. The Helicobacter pylori genome sequence: genetic factors for long life in the gastric mucosa. Effect of a waaL mutation on lipopolysaccharide composition, oxidative stress survival, and virulence in Erwinia amylovora.
PBP3 inhibition elicits adaptive responses in Pseudomonas aeruginosa. Surface swarming motility by Pectobacterium atrosepticum is a latent phenotype that requires O antigen and is regulated by quorum sensing.
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Evolutionary genomics of epidemic and nonepidemic strains of Pseudomonas aeruginosa. Di Lorenzo. Myeloid differentiation factor 2 MD-2 by hypoacylated lipopolysaccharide from a clinical isolate of Burkholderia cenocepacia. Persistent cystic fibrosis isolate Pseudomonas aeruginosa strain RP73 exhibits an under-acylated LPS structure responsible of its low inflammatory activity.
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Genetic and Functional Diversity of Pseudomonas aeruginosa Lipopolysaccharide. Heterogeneity of biofilms formed by nonmucoid Pseudomonas aeruginosa isolates from patients with cystic fibrosis. Parallel bacterial evolution within multiple patients identifies candidate pathogenicity genes.
Cationic antimicrobial peptides promote microbial mutagenesis and pathoadaptation in chronic infections. Helicobacter pylori genomic microevolution during naturally occurring transmission between adults. Interactions of bacterial adhesins with extracellular matrix and plasma proteins: pathogenic implications and therapeutic possibilities. Cystic fibrosis-niche adaptation of Pseudomonas aeruginosa reduces virulence in multiple infection hosts. A decade of Burkholderia cenocepacia virulence determinant research.
Role of structural variations of polysaccharide antigens in the pathogenicity of Gram-negative bacteria. Proteomic profiling of Burkholderia cenocepacia clonal isolates with different virulence potential retrieved from a cystic fibrosis patient during chronic lung infection. Data collected with the food records were used in the multivariable models to study the association between dietary intake, at the level of energy and macronutrient intake, and serum LPS activity.
In the current LPS-diet analyses, data from individuals who completed the record for a minimum of three days were included. From the food record entries, data on all food items for which an unambiguous match was found in the diet questionnaire were extracted for subsequent analyses.
For example, the numbers of cups of coffee, reported in the food record, were calculated and divided by the number of days the record was kept six to obtain the average of daily cups of coffee consumed. These values were then compared with the entries made in the diet questionnaires. Similarly, for the food record entries of fish dishes, meat dishes, poultry, and so on the items listed in the FFQ part of the diet questionnaire , a daily average consumption frequency was calculated.
Based on these calculated consumption frequencies, each food group was recoded according to the seven-point scale of the FFQ part of the diet questionnaire, to allow the comparison between the two methods.
The respective statistical comparisons were performed using Chi squared test, Mann-Whitney U-test, and t-test. Exploratory factor analysis maximal likelihood and varimax rotation was conducted to reveal underlying constructs within the FFQ in both the LPS-diet study and the validation study.
The factor score was the sum of the scores for all items associated with that particular factor multiplied by its corresponding factor loading. In the validation study, the factor analysis was additionally conducted for the 6-day food record data. Within each dietary pattern, for which we could identify a reasonable match between the FFQ and the food record derived patterns, quartiles were formed based on the factor scores.
The proportion of individuals classified into the same quartile, the same or adjacent quartile, or opposite quartile by the FFQ and the food record, was calculated. The Spearman correlation coefficient was used to calculate the correlation between the factor scores of the matched dietary patterns in the validation study.
Moreover, it was used to explore the correlations between serum LPS activity and dietary variables both the factor scores of the FFQ-derived dietary patterns, and the energy, macronutrient, and fibre intake calculated from the food records. The independent associations between these dietary variables, and serum LPS activity were investigated in a multivariable generalized linear model. Multivariable nutrient density substitution model was used to examine the associations between macronutrient intakes and LPS activity, as previously described However one of the macronutrients, in each analysis, was left out.
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It is a Gram-negative bacilli, motile and non-lactose fermenter. The genus can be divided into two species S. Last updated on June 30th, Although most prokaryotes cannot survive in nature without their cell walls, some do so naturally.
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