These warnings alert doctors and patients about drug effects that may be dangerous. Because of this increased risk of death, Abilify should not be used by this group of people.
But Abilify is similar to other drugs that have caused this side effect. They can recommend appropriate treatment options for your condition. Abilify may increase the risk of suicidal thoughts and behaviors in children and adults ages 24 years and younger. In clinical trials of adults taking Abilify, suicide did occur. Anyone who takes Abilify may be monitored by their doctor for new or worsening depression and suicidal thoughts or behaviors. Typically, your doctor will start you on a low dosage.
Your doctor will ultimately prescribe the smallest dosage that provides the desired effect. The following information describes dosages that are commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you.
Your doctor will determine the best dosage to fit your needs. It comes as tablets that are taken by mouth. These forms included:. Abilify is approved as an adjunct treatment for major depressive disorder MDD , which is also simply called depression.
Adjunct treatments are used in combination with other drugs to treat a certain condition. As an adjunct treatment for MDD, Abilify is used with other drugs. The typical starting dosage of Abilify for MDD is between 2 mg and 5 mg once each day. Then your dose will be increased by up to 5 mg each week until your depression symptoms are decreased.
The typical maintenance dosage range of Abilify for MDD is between 2 mg and 15 mg daily. For this use, the maximum daily dose of Abilify is 15 mg.
Abilify is approved for use in adults with manic and mixed episodes related to bipolar I disorder. For this condition, the typical starting dosage of Abilify in adults is 15 mg once daily. Valproate and lithium are other drugs used to treat bipolar disorder. The typical maintenance dosage of Abilify in adults with bipolar I disorder is 15 mg once daily.
However, up to 30 mg of Abilify daily may be used in some cases. And this is the maximum daily dose of Abilify for this condition.
Lithium and valproate are other drugs used to treat bipolar disorder. For adults with schizophrenia , the starting dosage of Abilify for this condition is typically 10 mg to 15 mg once daily. The typical maintenance dosage range of Abilify for schizophrenia is 10 mg to 30 mg daily.
However, dosages of 10 mg to 15 mg daily seem to be the most effective for the condition. Dosages greater than 15 mg daily may not be more effective than those less than 15 mg daily. For schizophrenia, the maximum daily dose of Abilify is 30 mg. Below we describe Abilify dosages for children with certain conditions that the drug is approved to treat.
Abilify is approved for use in children ages 13 to 17 years old with schizophrenia. The typical starting dosage of Abilify for this use is 2 mg once daily. After an additional 2 days, the doctor may increase the Abilify dose to 10 mg daily.
Doses between 10 mg and 30 mg have been studied in children. However, it seems that a dosage of 10 mg daily is just as effective as a dosage of 30 mg daily.
Abilify is approved for use in children ages 10 years to 17 years old with manic or mixed episodes related to bipolar I disorder.
After an additional 2 days, their doctor may increase their Abilify dose to 10 mg daily. If the doctor believes that your child needs a higher dose of Abilify, the dosage may be increased by 5 mg each day, up to a maximum of 30 mg daily.
Keep in mind that if your child is taking lithium or valproate along with Abilify, the recommended dosages of Abilify are the same as those described above.
Then the daily dose can be increased to 5 mg daily after at least 1 week. Following this, the daily dose can be increased to 10 mg to 15 mg daily. At least 1 week should pass between each dosage increase. If you miss a dose of Abilify, take the missed dose as soon as you remember.
Then take your next dose at the usual time. Never take two doses at once to make up for a missed dose. If you have any questions about when to take your next dose of Abilify after a missed dose, talk with your doctor or pharmacist. A medication timer may be useful, too.
Abilify is meant to be used as a long-term treatment. Abilify may also be used off-label for other conditions. Abilify is approved for use as an adjunct treatment in adults with major depressive disorder MDD. An adjunct treatment is used with other drugs for a specific condition. So as an adjunct treatment for MDD, Abilify is used with other drugs. MDD, which is often simply called depression , is a serious disease that affects your mood and actions.
People with MDD often feel sad or anxious. This condition may affect your daily life, and you possibly may not be able to eat or sleep like usual. Other symptoms of depression include feeling hopeless and not having interest in activities that you used to enjoy. Some people with depression may even have suicidal thoughts or behaviors, which are serious and may be life threatening. If you have new or worsening symptoms of depression, talk with your doctor right away.
Your doctor can recommend treatment options, which may include Abilify. In clinical trials , Abilify was effective in treating MDD. Two different studies compared MDD treatment with Abilify to that of a placebo treatment with no active drug. Test scores on this scale range from 0 to Abilify is approved to treat manic or mixed episodes related to bipolar I disorder.
For this use, Abilify can be given to adults and children ages 10 years and older. Bipolar disorder affects your brain and causes you to have changes in your mood and behavior. With bipolar I disorder, you may have manic episodes. During these episodes, you can feel energetic or extremely irritable. And your thoughts may be racing, making it difficult for you to concentrate.
During mixed episodes, you have manic symptoms and depression symptoms at the same time. Symptoms of depression can include feeling sad or hopeless, or lacking interest in activities that you used to enjoy. Some people with depression may have suicidal thoughts or behaviors, which are serious and may be life threatening.
With mixed episodes, you can have large changes in your mood. In clinical trials , Abilify was effective in treating manic and mixed episodes of bipolar I disorder. Below, we present some of the results of these studies. Four different studies looked at treatment with Abilify compared with that of a placebo treatment with no active drug.
Higher Y-MRS scores indicate worse mania symptoms than lower scores indicate. The studies showed that:. A clinical trial also compared treatment with Abilify plus either lithium or valproate to that of a placebo plus either lithium or valproate. This trial showed that:. Abilify is approved to treat schizophrenia in adults and children ages 13 years and older. Many different things can cause schizophrenia.
These include genetics and changes in certain neurotransmitters brain chemicals. Usually, schizophrenia begins to affect people during their teenage or young adult years. Symptoms of schizophrenia vary, but they can include:. In clinical trials, Abilify was effective in treating schizophrenia. Test scores from this scale range from 30 to These studies showed that:. Abilify is approved to treat irritability related to autism in children ages 6 years and older. In addition to the uses listed above, Abilify may be prescribed off-label for other uses.
And you may wonder if Abilify is used for certain other conditions. Below is information on other possible uses for Abilify. Anxiety can refer to a range of conditions, which are explained in a bit more detail below. These conditions include:. Some studies have shown that Abilify may be a treatment option for certain people with anxiety.
However, in some people, Abilify may actually cause symptoms of anxiety. So Abilify may not be right for everyone with anxiety. With GAD, you may feel restless or irritable. And you may have trouble falling or staying asleep.
This study showed that there may be a benefit from Abilify treatment in people with GAD. You may also have compulsions repetitive actions. For example, obsessions may include being afraid of germs or feeling that things need to be in a certain order.
Examples of compulsions may include constantly cleaning or repeatedly checking to make sure the oven is turned off. These obsessions and compulsions from OCD can cause anxiety.
These other treatments may include drugs called selective serotonin reuptake inhibitors SSRIs. So for this condition, your doctor may recommend that you take a low dose of Abilify along with an SSRI.
And that event may cause flashbacks and nightmares that lead to anxiety. For example, people with trouble sleeping may be unable to drive or focus on tasks. One study showed that Abilify may help people with sleep disorders to fall asleep more quickly and to sleep better. Another study looked at why Abilify may work for people with sleep disorders.
Because Abilify can cause insomnia as a side effect, a dose of the medication during the day may help people stay awake. And this could cause them to feel tired at night and be able to sleep better. But the drug is being studied for this use.
You may also have hyperactivity, which makes you unable to stay still. ADHD may also affect your ability to focus and learn. DMDD causes irritability, moodiness, and temper tantrums. In this study, people took Abilify along with methylphenidate Ritalin, Metadate. People with psychosis may have trouble figuring out what is real and what is imagined.
A review was done to see if Abilify may be a treatment option for people with psychosis. Abilify is still being studied for use in people with psychosis. If you have questions about using Abilify to treat psychosis, talk with your doctor. Abilify is approved for use in children with certain mental health conditions.
Below, we describe the use of Abilify for these conditions. Keep in mind that Abilify may increase the risk of suicidal thoughts and behaviors in children and young adults ages 24 and younger. Because of this risk, Abilify should be used cautiously in people ages 24 and younger. In clinical trials, Abilify was effective in treating schizophrenia in children ages 13 and older. In a study, Abilify treatment was compared with that of a placebo treatment with no active drug.
Test scores from this test range from 30 to Higher scores indicate worse schizophrenia symptoms than lower scores indicate. The study showed that:. Abilify is approved to treat manic or mixed episodes related to bipolar I disorder in children ages 10 years and older.
If you miss a dose of aripiprazole, take it as soon as you remember, unless it is closer to the time of your next dose. Do not double your next dose or take more than what is prescribed. If you miss an injection, call your doctor or pharmacist right away.
Discuss this with your healthcare provider. Avoid drinking alcohol or using illegal drugs while you are taking aripiprazole. They may decrease the benefits e. If an overdose occurs call your doctor or You may need urgent medical care. You may also contact the poison control center at A specific treatment to reverse the effects of aripiprazole does not exist. Headache, extrapyramidal symptoms, drowsiness, restlessness, fatigue, sedation, agitation, insomnia, anxiety, weight gain, cholesterol abnormalities, increased glucose, nausea, vomiting, constipation, application site rash MyCite , tremor.
Aripiprazole may increase the blood levels of a hormone called prolactin. Side effects of increased prolactin levels include females losing their period, production of breast milk and males losing their sex drive or possibly experiencing erectile problems.
Long term months or years of elevated prolactin can lead to osteoporosis or increased risk of bone fractures. Some people may develop muscle-related side effects while taking aripiprazole. Symptoms of EPS include restlessness, tremor, and stiffness. TD symptoms include slow or jerky movements that one cannot control, often starting in the mouth with tongue rolling or chewing movements.
Temperature regulation: Impaired core body temperature regulation may occur; caution with strenuous exercise, heat exposure, and dehydration. Second generation antipsychotics SGAs increase the risk of weight gain, high blood sugar, and high cholesterol.
This is also known as metabolic syndrome. Your healthcare provider may ask you for a blood sample to check your cholesterol, blood sugar, and hemoglobin A1c a measure of blood sugar over time while you take this medication. Information on healthy eating and adding exercise to decrease your chances of developing metabolic syndrome may be found at the following sites:. SGAs have been linked with higher risk of death, strokes, and transient ischemic attacks TIAs in elderly people with behavior problems due to dementia.
All antipsychotics have been associated with the risk of sudden cardiac death due to an arrhythmia irregular heart beat. To minimize this risk, antipsychotic medications should be used in the smallest effective dose when the benefits outweigh the risks. Your doctor may order an EKG to monitor for irregular heartbeat. Symptoms include confusion, fever, extreme muscle stiffness, and sweating. If any of these symptoms occur, contact your healthcare provider immediately.
All antipsychotics can cause sedation, dizziness, or orthostatic hypotension a drop in blood pressure when standing up from sitting or lying down. These side effects may lead to falls which could cause bone fractures or other injuries. This risk is higher for people with conditions or other medications that could worsen these effects.
With the approval of atypical antipsychotics, which are associated with a lower adverse effect burden than typical antipsychotics, consideration of their off-label use for the treatment of affective disorders and various other psychiatric disorders has become a viable option.
However, consideration should be given to the US FDA black box warning indicating that atypical antipsychotics may increase mortality risk, particularly in the elderly population with dementia-related psychosis. As a representative agent from the atypical antipsychotic class with a novel mechanism of action and a relatively low adverse effect burden, aripiprazole represents an interesting potential treatment for depressive and anxiety disorders.
If they are more than a week away, however, you might find that it is better to start aripiprazole to improve your motivation to study. You need to talk to your doctor or pharmacist before starting treatment with aripiprazole if any of the following apply to you:.
You can take aripiprazole as tablets, orodispersible tablets melts , liquid or a long-acting monthly injection. Make sure that you know your dose. If it's not written on the label, check with your pharmacist or doctor. This could be a mealtime, or when you brush your teeth.
For the normal coated tablets, swallow them whole with a drink of water - if you chew them, they taste bitter. To take an orodispersible tablet melt , put one on your tongue and let it dissolve there. You can also dissolve it in some water if you prefer. A doctor or nurse can give you a fast-acting dose of aripiprazole by injection if you are very agitated. You can have a tablet at the same time — under the supervision of a doctor — which will make the effect last longer.
If you start receiving the long-acting injection, you may also have be given some tablets to take until the medicine level is high enough in your body.
If you forget to take your medicine for a few days, you may start getting your old symptoms back. Talk to your doctor if this happens. Once you start taking an antipsychotic medicine, the brain adjusts to having a new level of dopamine around. If you stop taking it suddenly, the balance starts to change, and your old symptoms could return. You could also experience some unpleasant withdrawal symptoms like headache, feeling sick and sleep problems.
They will work with you to reduce your dose gradually rather than stopping suddenly. The speed at which you reduce depends on how unwell you were and how long you have been on aripiprazole. If you have taken more aripiprazole than the dosage recommended by the doctor who prescribed it to you, you must get medical help immediately — even if you do not feel any different. Take a friend with you if possible, in case you start to feel ill on the way. While taking aripiprazole, some people may think about hurting themselves or taking their own lives.
You must go straight to hospital with your tablets if you have any of these thoughts. Aripiprazole can cause serious side effects like allergic reactions difficulty breathing, swelling of your face or throat, itching skin lumps and other serious symptoms, which are listed under the 'Side effects' tab. Go to a hospital if you experience any of these effects, taking your medicine with you.
Stopping aripiprazole suddenly might cause unpleasant withdrawal effects — go to your doctor if you want to stop, or if you are having these effects. You might feel sleepy or dizzy in the first few days after taking aripiprazole — do not drive a car, ride a bike or operate machines until you see how this affects you. If you take aripiprazole while you are pregnant, there is nothing to suggest it will harm the developing baby, though the medication can cause symptoms in newborn babies.
Use good contraception while you are taking aripiprazole and tell your doctor if you want to start trying for a baby. You might get any of the following signs:. While taking aripiprazole, some people think about hurting themselves or taking their own lives.
This can happen to anyone, including people who are under Take a friend or family member with you to keep you safe on the way. Stop taking your medicine and seek medical help straight away if you get any of the following symptoms:. If you start to experience muscle spasms or abnormal bodily movements that you cannot control, you should go and see your doctor as soon as possible.
Antipsychotic medications can cause a wide variety of problems with movement such as tremors, restlessness, agitation and unusual movement of the lips, tongue, hands or pelvis. If the movements are severe then you might find it difficult to speak, eat or breathe.
These are called extrapyramidal side effects EPS. Aripiprazole is less likely to cause these movements than some of the other antipsychotics. A subgroup of the movement side effects is called tardive dyskinesia. This is an uncommon side effect of aripiprazole. It occurs in less than one in people and can be a legacy of taking earlier antipsychotics.
The first sign might be some movements of your tongue that you cannot control, and they may be quite regular and rhythmic. The problem with tardive dyskinesia is that it might not stop, even if you stop taking your medicine.
You should have your weight, height, waist circumference and blood pressure checked regularly while you are taking aripiprazole. Your doctor should also do blood tests to check your liver, blood sugar, and some hormones before and regularly during your treatment. You may also have a heart test called an electrocardiogram ECG before you start treatment - and periodically while taking aripiprazole - if you are at risk of heart disease. In the first two or three weeks of taking aripiprazole, side effects such as feeling agitated and restless, or feeling sick may make you feel generally worse.
They should wear off quite quickly but if they are a problem, speak to your doctor or care team. The side effects that come with aripiprazole are different to those of many other antipsychotics, but they can be serious. Do not stop taking the tablets until you talk to your doctor, or you may get withdrawal symptoms as well. There are other side effects that you can get when taking this medicine — we have only included the most common ones here.
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